Bronchodilator delivery with metered-dose inhaler during mechanical ventilation

Crit Care. 2000;4(4):227-34. doi: 10.1186/cc698. Epub 2000 Jul 11.


The delivery of bronchodilators with metered-dose inhaler (MDI) in mechanically ventilated patients has attracted considerable interest in recent years. This is because the use of the MDI has several advantages over the nebulizer, such as reduced cost, ease of administration, less personnel time, reliability of dosing and a lower risk of contamination. A spacer device is fundamental in order to demonstrate the efficacy of the bronchodilatory therapy delivered by MDI. Provided that the technique of administration is appropriate, MDIs are as effective as nebulizers, despite a significantly lower dose of bronchodilator given by the MDI.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Bronchodilator Agents / administration & dosage*
  • Bronchodilator Agents / blood
  • Bronchodilator Agents / pharmacokinetics
  • Cost-Benefit Analysis
  • Drug Monitoring
  • Equipment Design
  • Humans
  • Nebulizers and Vaporizers / economics
  • Nebulizers and Vaporizers / standards*
  • Respiration, Artificial / instrumentation*


  • Bronchodilator Agents