[Genome methylation and its role in functioning of the eukaryotic organism]

Genetika. 2000 Nov;36(11):1475-86.
[Article in Russian]

Abstract

Methylation is a modification that changes the structure and functional status of DNA. Hence it is interesting to study the effect of methylation on basic processes occurring in living cells. In this review, the role of DNA methylation in recombination, replication, transcription regulation, imprinting, tumorigenesis, and tumor progression is considered.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism
  • CpG Islands
  • DNA / genetics
  • DNA / metabolism*
  • DNA / physiology
  • DNA Modification Methylases / metabolism
  • DNA Replication
  • DNA-Binding Proteins / metabolism
  • Eukaryotic Cells / metabolism
  • Eukaryotic Cells / physiology
  • Genome*
  • Genomic Imprinting
  • Humans
  • Methylation
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Protein Structure, Tertiary
  • Recombination, Genetic
  • Transcription, Genetic

Substances

  • Chromatin
  • DNA-Binding Proteins
  • DNA
  • DNA Modification Methylases