Retinal toxicity of triamcinolone acetonide in silicone-filled eyes

Ophthalmic Surg Lasers. 2000 Nov-Dec;31(6):474-8.


Objective: To determine the retinal toxicity of triamcinolone acetonide at different doses in vitrectomized, silicone-filled rabbit eyes.

Materials and methods: Vitrectomy with silicone oil placement was performed in 32 rabbit eyes. A dosage of 1 mg/0.025 mL, 2 mg/0.05 mL, or 4 mg/0.1 mL of triamcinolone acetonide was injected intravitreally in the study group eyes; the control group received 0.1 mL of sterile saline. Electroretinography and retinal histology were performed to evaluate toxicity.

Results: No retinal toxicity was seen in the groups given 1, 2, and 4 mg of triamcinolone acetonide or in the control group. ERG and histologic sections in all groups were normal. No drug was visible in the vitreous cavity at the end of the 140-day period (average) in eyes injected with 4 mg of triamcinolone acetonide.

Conclusions: Up to 4 mg of triamcinolone acetonide can be safely injected in silicone-filled, vitrectomized eyes without any significant retinal toxicity.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Drug Interactions
  • Electroretinography / drug effects
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / toxicity*
  • Injections
  • Male
  • Rabbits
  • Retina / drug effects*
  • Retina / pathology
  • Retina / physiopathology
  • Silicone Oils / administration & dosage*
  • Toxicity Tests
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / toxicity*
  • Vitrectomy / methods*
  • Vitreous Body


  • Glucocorticoids
  • Silicone Oils
  • Triamcinolone Acetonide