Multiple antibiotic-resistant bacteria in long-term-care facilities: An emerging problem in the practice of infectious diseases

Clin Infect Dis. 2000 Dec;31(6):1414-22. doi: 10.1086/317489. Epub 2000 Nov 29.


Long-term-care facilities (LTCFs) are becoming a major component of the health care delivery system. The management of infections with antibiotic-resistant bacteria in elderly patients in LTCFs is presenting new challenges to our current therapeutic armamentarium. Among the enteric bacilli, resistance to ceftazidime, beta-lactam/beta-lactamase-inhibitor combinations, and trimethoprim-sulfamethoxazole present the foremost problems. Quinolone-resistant gram-negative and gram-positive bacteria are increasing in frequency because of the widespread use of these agents in empirical treatment. Among the resistant gram-positive organisms, methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci, and vancomycin-resistant enterococci are the most feared pathogens. Education, antibiotic control measures, and fundamental epidemiological and scientific research are advocated as important preventive measures.

Publication types

  • Review

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / drug effects*
  • Bacterial Infections / epidemiology*
  • Bacterial Infections / microbiology*
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Health Facilities*
  • Humans
  • Long-Term Care*


  • Anti-Bacterial Agents