Inhibitory Effects of Indole-3-carbinol on Invasion and Migration in Human Breast Cancer Cells

Breast Cancer Res Treat. 2000 Sep;63(2):147-52. doi: 10.1023/a:1006495824158.

Abstract

Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anticarcinogenic Agents / pharmacology*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / prevention & control
  • Cadherins / analysis
  • Cell Adhesion
  • Cell Movement
  • Female
  • Humans
  • Indoles / pharmacology*
  • Neoplasm Invasiveness
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases / genetics
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins*

Substances

  • Anticarcinogenic Agents
  • Cadherins
  • Indoles
  • Tumor Suppressor Proteins
  • indole-3-carbinol
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human