Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice

Behav Brain Res. 2000 Dec 20;117(1-2):147-51. doi: 10.1016/s0166-4328(00)00298-9.


We investigated the effect of the nootropic substance oxiracetam on the impairment of memory induced in mice by the non-competitive NMDA antagonist MK-801. Memory capacities of animals having different experience were evaluated using the elevated plus-maze test. Oxiracetam was injected immediately after the acquisition session(s), MK-801 was given 30 min before the retention session which followed 24 h after the acquisition session(s). In slightly experienced animals (Section 3.1), oxiracetam (3 and 30 mg/kg, s.c.) prevented MK-801 (0.15 mg/kg, i.p.) induced memory deficits characterized by a prolongation of the transfer latency. In well-trained animals (Section 3.2), oxiracetam (30 mg/kg, s.c.) attenuated MK-801 (0.15,0. 25 and 0.4 mg/kg, i.p.) induced amnesia for a spatial orientation in the elevated plus-maze. These results show that oxiracetam interacted with the glutamatergic NMDA receptor system and forestalled the impairment of retrieval of long-term memory. The results also justify the usage of the elevated plus-maze method in the evaluation of potential anti-amnesic or nootropic drugs.

MeSH terms

  • Amnesia / chemically induced
  • Amnesia / prevention & control*
  • Analysis of Variance
  • Animals
  • Dizocilpine Maleate / adverse effects*
  • Excitatory Amino Acid Antagonists / adverse effects*
  • Female
  • Maze Learning / drug effects*
  • Memory / drug effects*
  • Mice
  • Nootropic Agents / pharmacology*
  • Pyrrolidines / pharmacology*
  • Random Allocation
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors


  • Excitatory Amino Acid Antagonists
  • Nootropic Agents
  • Pyrrolidines
  • Receptors, N-Methyl-D-Aspartate
  • Dizocilpine Maleate
  • oxiracetam