Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'

Nat Med. 2000 Dec;6(12):1406-10. doi: 10.1038/82231.


Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.

MeSH terms

  • Antigen Presentation*
  • CD8-Positive T-Lymphocytes / immunology*
  • Histocompatibility Antigens Class II / administration & dosage*
  • Immune Tolerance
  • Immunologic Techniques*
  • Liposomes
  • Peptides / administration & dosage*
  • Vaccination / methods


  • Histocompatibility Antigens Class II
  • Liposomes
  • Peptides