The influence of Helicobacter pylori infection on gastrin and somatostatin values present in serum

Hepatogastroenterology. 2000 Sep-Oct;47(35):1482-4.


Background/aims: Recent studies on the role of Helicobacter pylori in pathogenesis of duodenal ulcers have focused on the mechanism by which H. pylori infections causes exaggerated gastrin release.

Methodology: We compared the gastrin and somatostatin serum values between two groups of patients; 37 H. pylori-positive ones and 29 H. pylori-negative ones. We applied radioimmunoassay technique to determine the gastrin and somatostatin values in serum. H. pylori was confirmed by urease test and by histopathological color according to Giemsa.

Results: The level of gastrin in the serum of Helicobacter pylori-positive patients with chronic gastritis were significantly higher in relation to H. pylori-negative patients. The somatostatin concentration in the sera of H. pylori-positive patients with duodenal ulcer (16.27 +/- 9.49 pg/mL) were less in comparison with those without duodenal ulcer (23.25 +/- 13.59 pg/mL).

Conclusions: The results suggest that H. pylori infection suppresses the somatostatin secretion.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Gastrins / blood*
  • Gastritis / blood*
  • Gastritis / complications
  • Helicobacter Infections / blood*
  • Helicobacter Infections / complications
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Radioimmunoassay
  • Somatostatin / blood*


  • Gastrins
  • Somatostatin