The DNA damage response: putting checkpoints in perspective

Nature. 2000 Nov 23;408(6811):433-9. doi: 10.1038/35044005.

Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

Publication types

  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle / genetics
  • Cell Cycle Proteins*
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage*
  • DNA Repair
  • DNA-Binding Proteins
  • Forecasting
  • Humans
  • Protein Kinases / physiology
  • Protein-Serine-Threonine Kinases / physiology
  • Signal Transduction*
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human
  • Checkpoint Kinase 1
  • Protein-Serine-Threonine Kinases