Roles of Mast Cells and Basophils in Innate and Acquired Immunity

Curr Opin Immunol. 2000 Dec;12(6):624-31. doi: 10.1016/s0952-7915(00)00154-0.


There have been several recent advances in knowledge about mast cells and basophils in immune responses, of which some are particularly important: a role has been found for heparin in the storage of certain proteases and other mediators in mast cell cytoplasmic granules; an important role for mast cells in the development of several chronic aspects of an asthma model in mice has been discovered; and a new approach has been developed, based on the generation of mast cells from embryonic stem cells in vitro, to investigate mast cell function in vitro or in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basophils / immunology*
  • Humans
  • Immunity, Active / immunology
  • Immunity, Innate / immunology
  • Immunoglobulin E / immunology
  • Mast Cells / immunology*
  • Parasites / immunology
  • Parasitic Diseases / immunology


  • Immunoglobulin E