Present difficulties and future promise of MHC multimers in autoimmune exploration

Curr Opin Immunol. 2000 Dec;12(6):670-5. doi: 10.1016/s0952-7915(00)00161-8.


Class I tetramers have been used to track cytotoxic T cells during bacterial and viral infections. During the past year, the use of such molecules has revealed important information about the role of CD8(+) T cells in autoimmune diabetes. Furthermore, class II multimers have been produced and successfully used to stain autoreactive CD4(+) T cells from patients with rheumatoid arthritis or Borrelia-burgdorferi-induced Lyme arthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens / immunology
  • Arthritis, Rheumatoid / immunology
  • Autoimmunity* / immunology
  • Borrelia burgdorferi Group
  • Diabetes Mellitus, Type 1 / immunology
  • Forecasting
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Lyme Disease / immunology
  • Peptides / immunology
  • T-Lymphocytes / immunology*


  • Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Peptides