The role of different subsets of T regulatory cells in controlling autoimmunity

Curr Opin Immunol. 2000 Dec;12(6):676-83. doi: 10.1016/s0952-7915(00)00162-x.


T regulatory cells-in addition to clonal deletion and anergy-are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Differentiation
  • Clonal Anergy / immunology
  • Cytokines / immunology
  • Humans
  • Leukocyte Common Antigens / immunology
  • Receptors, Interleukin-2 / immunology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology


  • Cytokines
  • Receptors, Interleukin-2
  • Leukocyte Common Antigens