Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

Curr Opin Chem Biol. 2000 Dec;4(6):632-8. doi: 10.1016/s1367-5931(00)00151-4.


The pathway for glycosylphosphatidylinositol-anchor biosynthesis consists of at least 10 reaction steps. Many of the genes encoding the enzymes and regulators involved in this pathway have been recently cloned and their products characterised. These studies have revealed the common and also different characteristics of glycosylphosphatidyl-inositol biosynthesis enzymes in different organisms, leading to the development of species-specific inhibitors of the pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylglucosamine / biosynthesis
  • Acylation
  • Animals
  • Eukaryota / metabolism
  • Glycosylphosphatidylinositols / biosynthesis*
  • Mannose / chemistry
  • Saccharomyces cerevisiae / metabolism


  • Glycosylphosphatidylinositols
  • Mannose
  • Acetylglucosamine