Intrathecal baclofen for dystonia: benefits and complications during six years of experience

Mov Disord. 2000 Nov;15(6):1242-7. doi: 10.1002/1531-8257(200011)15:6<1242::aid-mds1028>3.0.co;2-z.

Abstract

Fourteen patients with primary or secondary dystonia received intrathecal baclofen (ITB) through an implanted pump following a trial dose. Patients were selected for ITB trial if they had clinically unsatisfactory responses to oral antidystonic medications, including oral baclofen. Patients were rated using the Burke-Fahn-Marsden rating scale by a blinded rater after the dose of ITB was optimized. Five patients experienced improvement in symptoms as determined by a change in rating scale scores, although only two had a clear clinical benefit. Etiology of dystonia did not determine the efficacy of ITB therapy, as benefit or failure was seen in both primary and secondary dystonia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Baclofen / administration & dosage*
  • Baclofen / adverse effects
  • Dystonia / drug therapy*
  • Female
  • Humans
  • Infusion Pumps, Implantable
  • Injections, Spinal
  • Male
  • Middle Aged
  • Muscle Relaxants, Central / administration & dosage*
  • Muscle Relaxants, Central / adverse effects
  • Treatment Outcome

Substances

  • Muscle Relaxants, Central
  • Baclofen