Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents

J Magn Reson Imaging. 2000 Dec;12(6):991-1003. doi: 10.1002/1522-2586(200012)12:6<991::aid-jmri26>;2-1.


A technique for the simultaneous measurement of three vascular parameters: blood flow (Frho), blood volume (v(b)), and the capillary permeability-surface area product (PSrho) in breast tumors using dynamic contrast-enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T(1), rapid temporal sampling, measurement of the arterial input function, and use of a distributed parameter tracer kinetic model. Parameter measurements are compared that were determined using two contrast agents of different molecular weights, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA; 0.6 kDa) and Gadomer-17 (17 kDa), in 18 spontaneous canine mammary tumors. Measurements of Frho and v(b) corresponded well with literature values, and the mean PSrho measured using Gd-DTPA was a factor of 15 higher than that measured using Gadomer-17. J. Magn. Reson. Imaging 2000;12:991-1003.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Flow Velocity / physiology*
  • Blood Volume / physiology*
  • Capillary Permeability / physiology*
  • Contrast Media*
  • Dog Diseases / diagnosis
  • Dog Diseases / physiopathology
  • Dogs
  • Female
  • Gadolinium DTPA*
  • Gadolinium*
  • Magnetic Resonance Imaging*
  • Mammary Glands, Animal / blood supply
  • Mammary Neoplasms, Experimental / blood supply*
  • Phantoms, Imaging
  • Sensitivity and Specificity


  • Contrast Media
  • gadomer 17
  • Gadolinium
  • Gadolinium DTPA