Role of Cbfa1 in osteoblast differentiation and function

Semin Cell Dev Biol. 2000 Oct;11(5):343-6. doi: 10.1006/scdb.2000.0188.


Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Differentiation / genetics*
  • Core Binding Factor Alpha 1 Subunit
  • Gene Expression Regulation, Developmental*
  • Humans
  • Neoplasm Proteins*
  • Osteoblasts / cytology*
  • Osteogenesis / genetics*
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Transcription, Genetic


  • Core Binding Factor Alpha 1 Subunit
  • Neoplasm Proteins
  • Transcription Factors