Intervening in atherogenesis: lessons from diabetes

Hosp Pract (1995). 2000 Nov 15;35(11):25-7, 32, 35-9. doi: 10.3810/hp.2000.11.218.

Abstract

Age-related atherogenesis resembles diabetes, a model in which glucose looms as an important culprit. Within the body, the sugar becomes a glue able to harden and obstruct blood vessels while also activating such cells as macrophages and T lymphocytes. A new discovery is that large quantities of glycation endproducts may arrive preformed in foods prepared by routine cooking methods.

Publication types

  • Review

MeSH terms

  • Arteriosclerosis / physiopathology*
  • Arteriosclerosis / prevention & control*
  • Cooking
  • Diabetes Mellitus / physiopathology
  • Diet, Atherogenic
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Glucose / metabolism
  • Glycation End Products, Advanced / blood
  • Glycation End Products, Advanced / chemistry
  • Guanidines / chemistry
  • Guanidines / pharmacology
  • Guanidines / therapeutic use
  • Humans
  • Models, Biological

Substances

  • Enzyme Inhibitors
  • Glycation End Products, Advanced
  • Guanidines
  • Glucose
  • pimagedine