Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB

Mol Cell Biochem. 2000 Sep;212(1-2):5-9.

Abstract

The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.

Publication types

  • Review

MeSH terms

  • Activating Transcription Factor 1
  • Amino Acid Sequence
  • Animals
  • Cyclic AMP Response Element Modulator
  • Cyclic AMP Response Element-Binding Protein / chemistry
  • Cyclic AMP Response Element-Binding Protein / metabolism*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Humans
  • Memory / physiology
  • Molecular Sequence Data
  • Repressor Proteins*
  • Signal Transduction
  • Transcription Factors / chemistry
  • Transcription, Genetic
  • Transcriptional Activation*

Substances

  • Activating Transcription Factor 1
  • Cyclic AMP Response Element-Binding Protein
  • DNA-Binding Proteins
  • Repressor Proteins
  • Transcription Factors
  • Cyclic AMP Response Element Modulator