Abstract
The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.
MeSH terms
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Activating Transcription Factor 1
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Amino Acid Sequence
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Animals
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Cyclic AMP Response Element Modulator
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Cyclic AMP Response Element-Binding Protein / chemistry
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Cyclic AMP Response Element-Binding Protein / metabolism*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism
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Humans
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Memory / physiology
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Molecular Sequence Data
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Repressor Proteins*
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Signal Transduction
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Transcription Factors / chemistry
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Transcription, Genetic
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Transcriptional Activation*
Substances
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Activating Transcription Factor 1
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins
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Repressor Proteins
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Transcription Factors
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Cyclic AMP Response Element Modulator