LIAN 3.0: detecting linkage disequilibrium in multilocus data. Linkage Analysis

Bioinformatics. 2000 Sep;16(9):847-8. doi: 10.1093/bioinformatics/16.9.847.


LIAN is a program to test the null hypothesis of linkage equilibrium for multilocus data. LIAN incorporates both a Monte Carlo method as well as a novel algebraic method to carry out the hypothesis test. The program further returns the genetic diversity of the sample and the pairwise distances between its members.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping / methods*
  • Computational Biology / methods*
  • Genetic Variation
  • Haplotypes
  • Linkage Disequilibrium / genetics*
  • Models, Genetic*
  • Monte Carlo Method
  • Neisseria meningitidis / genetics
  • Software*
  • User-Computer Interface