B cells and antibodies in CNS demyelinating disease

J Neuroimmunol. 2001 Jan 1;112(1-2):1-14. doi: 10.1016/s0165-5728(00)00409-4.


There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps opposing roles for B cells versus antibody.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies / physiology*
  • Antigen Presentation
  • Antigen-Antibody Complex / physiology
  • Autoantibodies / biosynthesis
  • B-Lymphocytes / physiology*
  • Brain / immunology
  • Encephalomyelitis, Autoimmune, Experimental / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Humans
  • Multiple Sclerosis / etiology*
  • Multiple Sclerosis / immunology
  • Phagocytosis
  • Plasma Cells / physiology


  • Antibodies
  • Antigen-Antibody Complex
  • Autoantibodies