Abstract
During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca(2+)-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca(2+)-dependent manner, and the role of the complex ALG-2/AIP as a possible modulator at the interface between cell proliferation and cell death is discussed.
MeSH terms
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Amino Acid Sequence
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Animals
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Apoptosis Regulatory Proteins
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Apoptosis*
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COS Cells
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Calcium / metabolism*
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Calcium Signaling
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Calcium-Binding Proteins / biosynthesis
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Calcium-Binding Proteins / chemistry
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism*
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Cell Cycle Proteins*
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Cell Differentiation
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Cell Division
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Consensus Sequence
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DNA-Binding Proteins*
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E2F Transcription Factors
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Endosomal Sorting Complexes Required for Transport
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Humans
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Immunohistochemistry
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Models, Chemical
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Molecular Sequence Data
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Retinoblastoma-Binding Protein 1
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Sequence Alignment
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Transcription Factor DP1
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Transcription Factors / metabolism
Substances
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Apoptosis Regulatory Proteins
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Calcium-Binding Proteins
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Carrier Proteins
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Cell Cycle Proteins
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DNA-Binding Proteins
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E2F Transcription Factors
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Endosomal Sorting Complexes Required for Transport
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PDCD6 protein, human
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PDCD6IP protein, human
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Retinoblastoma-Binding Protein 1
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Transcription Factor DP1
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Transcription Factors
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Calcium