[Collapsing glomerulopathy and cytomegalovirus, what are the links?]

Presse Med. 2000 Nov 4;29(33):1815-7.
[Article in French]

Abstract

Background: Collapsing glomerulopathy is a form of focal and segmental glomerulosclerosis which occurs preferentially in black people. It causes severe nephrotic syndrome and quickly progresses towards end-stage renal failure.

Case report: We report the case of a 16-year-old black girl from Guadeloupe who was admitted for tetanus and edema in 1996. She had hypoparathyroidism, renal failure and a nephrotic syndrome as well as cytomegalovirus infection. Renal biopsy showed collapsing glomerulopathy. The renal function improved on glucocorticoid and ganciclovir therapy and her serum creatinine stabilized around 250 mumol/l for two years.

Discussion: Collapsing nephropathy is the cellular type of focal and segmental glomerulosclerosis. The main etiology is the human immunodeficiency virus. A viral infection may be involved in its pathogenesis. Other viruses could be linked with this nephropathy. This case report relates a case associated with a cytomegalovirus viruria. The clinical course might be related with the antiviral treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • AIDS-Associated Nephropathy / pathology*
  • AIDS-Related Opportunistic Infections / pathology*
  • Adolescent
  • African Continental Ancestry Group*
  • Biopsy
  • Cytomegalovirus Infections / pathology*
  • Female
  • Glomerulosclerosis, Focal Segmental / pathology*
  • Humans
  • Kidney Failure, Chronic / pathology
  • Kidney Function Tests
  • Kidney Glomerulus / pathology
  • Prognosis