Mydriasis and glaucoma: exploding the myth. A systematic review

Diabet Med. 2000 Oct;17(10):693-9. doi: 10.1046/j.1464-5491.2000.00368.x.


Aims: To investigate the risk of inducing acute glaucoma following mydriasis.

Methods: Systematic review of published research 1933-1999.

Results: The risk of inducing acute glaucoma following mydriasis with tropicamide alone is close to zero, no case being identified. The risk with long-acting or combined agents is between 1 in 3,380 and 1 in 20,000. The presence of chronic glaucoma constitutes no additional risk.

Conclusions: Mydriasis with tropicamide alone is safe even in people with chronic glaucoma. It should be advised in all patients when thorough retinal examination is indicated.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Glaucoma / etiology*
  • Humans
  • Mydriasis / complications*
  • Mydriatics / adverse effects*
  • Risk Factors
  • Safety
  • Tropicamide / adverse effects*


  • Mydriatics
  • Tropicamide