Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast

Biochim Biophys Acta. 2000 Dec 15;1529(1-3):155-63. doi: 10.1016/s1388-1981(00)00145-1.


The model eukaryote Saccharomyces cerevisiae (budding yeast) has provided significant insight into sterol homeostasis. The study of sterol metabolism in a genetically amenable model organism such as yeast is likely to have an even greater impact and relevance to human disease with the advent of the complete human genome sequence. In addition to definition of the sterol biosynthetic pathway, almost to completion, the remarkable conservation of other components of sterol homeostasis are described in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins*
  • Ergosterol / biosynthesis
  • Gene Expression Regulation
  • Genomics
  • Homeostasis
  • Humans
  • Membrane Glycoproteins*
  • Microscopy, Electron, Scanning
  • Proteins / genetics
  • Proteins / metabolism
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / ultrastructure
  • Sterol O-Acyltransferase / metabolism
  • Sterols / biosynthesis*


  • Carrier Proteins
  • Membrane Glycoproteins
  • NPC1 protein, human
  • Proteins
  • Sterols
  • Sterol O-Acyltransferase
  • Ergosterol