Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake

Biochim Biophys Acta. 2000 Dec 15;1529(1-3):276-86. doi: 10.1016/s1388-1981(00)00154-2.


High-density lipoproteins (HDL) play an important role in protection against atherosclerosis by mediating reverse cholesterol transport - the transport of excess cholesterol from peripheral tissues to the liver for disposal. SR-BI is a cell surface receptor for HDL and other lipoproteins (LDL and VLDL) and mediates the selective uptake of lipoprotein cholesterol by cells. Overexpression or genetic ablation of SR-BI in mice revealed that it plays an important role in HDL metabolism and reverse cholesterol transport and protects against atherosclerosis in mouse models of the disease. If it plays a similar role in humans then it may be an attractive target for therapeutic intervention. We will review some of the recent advances in the understanding of SR-BI's physiological role and cellular function in lipoprotein metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apolipoproteins / metabolism
  • Biological Transport
  • CD36 Antigens / genetics
  • CD36 Antigens / metabolism*
  • Carrier Proteins / metabolism
  • Cell Line
  • Cell Membrane / metabolism
  • Cholesterol Ester Transfer Proteins
  • Coronary Artery Disease / metabolism*
  • Disease Models, Animal
  • Glycoproteins*
  • Humans
  • Lipoproteins, HDL / metabolism*
  • Membrane Proteins*
  • Mice
  • Mice, Transgenic
  • Models, Chemical
  • Receptors, Immunologic*
  • Receptors, Lipoprotein / genetics
  • Receptors, Lipoprotein / metabolism*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Substrate Specificity


  • Apolipoproteins
  • CD36 Antigens
  • CETP protein, human
  • Carrier Proteins
  • Cholesterol Ester Transfer Proteins
  • Glycoproteins
  • Lipoproteins, HDL
  • Membrane Proteins
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B