Ileorectal anastomosis is appropriate for a subset of patients with familial adenomatous polyposis

Gastroenterology. 2000 Dec;119(6):1454-60. doi: 10.1053/gast.2000.20180.


Background & aims: This study reevaluates the risk of rectal cancer and the frequency of subsequent proctectomy for nonmalignant causes in patients with familial adenomatous polyposis (FAP) who have undergone colectomy with ileorectal anastomosis (IRA). Potential risk factors for rectal cancer in this setting are also examined, and recommendations for the choice of surgical procedure are made.

Methods: The national polyposis registries in Denmark, Finland, The Netherlands, and Sweden included 659 patients undergoing surgery with IRA in 1940-1997. Kaplan-Meier analysis and Cox regression analysis were performed to evaluate cumulative risk, survival, and predictive risk factors.

Results: Rectal carcinoma was diagnosed in 47 patients, with a cumulative 40-year risk of 0.32. The cumulative risk according to chronologic age was 0.30 at age 60, and higher in patients undergoing surgery above age 25 (P = 0.0016). Chronologic age was the only independent risk factor (P = 0.0016). The cumulative 5-year survival rate after rectal carcinoma was 0.60. The apc mutation was known in 167 patients, of whom 7 had rectal cancer. The cumulative 40-year risk of secondary proctectomy was 0.70, and higher in patients with a mutation in codon 1250-1500 than outside this region (P = 0.005). However, all 7 rectal cancers were found in the latter group. None of the 18 patients with attenuated FAP (mutation in codon 0-200 or >1500) had a secondary proctectomy.

Conclusions: IRA is recommended in (1) young patients with few rectal adenomas and a family history of a mild phenotype and (2) patients with attenuated FAP (a mutation in codon 0-200 or >1500), provided there is acceptance of life-long rectal surveillance. Patients with many rectal polyps and/or a family history of severe polyposis should be offered a restorative proctocolectomy with an ileal pouch-anal anastomosis.

MeSH terms

  • Adenoma / genetics
  • Adenoma / surgery
  • Adenomatous Polyposis Coli / genetics
  • Adenomatous Polyposis Coli / surgery*
  • Adolescent
  • Adult
  • Aged
  • Aging
  • Anastomosis, Surgical*
  • Child
  • Colectomy
  • Female
  • Humans
  • Ileum / surgery*
  • Male
  • Middle Aged
  • Mutation
  • Rectal Neoplasms / genetics
  • Rectal Neoplasms / secondary
  • Rectal Neoplasms / surgery
  • Rectum / surgery*
  • Reoperation
  • Risk Factors
  • Survival Analysis