Leukocyte-facilitated entry of intracellular pathogens into the central nervous system

Microbes Infect. 2000 Nov;2(13):1609-18. doi: 10.1016/s1286-4579(00)01317-4.


Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / pathogenicity*
  • Blood-Brain Barrier / immunology
  • Brain / blood supply
  • Cell Movement
  • Central Nervous System / immunology
  • Central Nervous System / microbiology
  • Central Nervous System / virology
  • Central Nervous System Infections / immunology
  • Central Nervous System Infections / microbiology*
  • Central Nervous System Infections / virology
  • Cerebrospinal Fluid / microbiology
  • Endothelium, Vascular / physiology
  • Humans
  • Leukocytes / microbiology*
  • Phagocytes / microbiology
  • Phagocytes / physiology
  • Viruses / pathogenicity*