Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

Diabetes Metab Res Rev. Nov-Dec 2000;16(6):434-41. doi: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr159>;2-8.


Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism. They act as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as the insulin receptor, and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. In addition, differential IRS tissue- and developmental-specific expression patterns may contribute to specificity in their signaling potential.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Humans
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Phosphoproteins / physiology*
  • Rats
  • Receptor, Insulin / physiology*
  • Signal Transduction / physiology*
  • src Homology Domains


  • Adaptor Proteins, Signal Transducing
  • IRS1 protein, human
  • IRS2 protein, human
  • IRS3P protein, human
  • IRS4 protein, human
  • IRS4 protein, rat
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Irs1 protein, mouse
  • Irs1 protein, rat
  • Irs2 protein, mouse
  • Irs2 protein, rat
  • Irs3 protein, mouse
  • Irs3 protein, rat
  • Irs4 protein, mouse
  • Phosphoproteins
  • Receptor, Insulin