Natural antibodies and complement link innate and acquired immunity

Immunol Today. 2000 Dec;21(12):624-30. doi: 10.1016/s0167-5699(00)01754-0.

Abstract

Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus-antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology*
  • Antibodies, Viral / immunology*
  • Antibody Formation*
  • Antigen-Antibody Complex / immunology
  • Antigens, Viral / immunology
  • Bacteremia / immunology
  • Bacterial Infections / immunology
  • Complement Activation
  • Complement System Proteins / physiology*
  • Germ-Free Life
  • Humans
  • Immunity, Innate*
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphocyte Subsets / immunology
  • Macrophages / immunology
  • Mice
  • Mucous Membrane / immunology
  • Spleen / immunology
  • Viremia / immunology
  • Virus Diseases / immunology

Substances

  • Antibodies, Bacterial
  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Antigens, Viral
  • Complement System Proteins