Molecular Interactions of Coreceptor CD8 and MHC Class I: The Molecular Basis for Functional Coordination With the T-cell Receptor

Immunol Today. 2000 Dec;21(12):630-6. doi: 10.1016/s0167-5699(00)01750-3.

Abstract

In recent years, substantial progress has been made towards understanding the molecular basis for CD8 binding to class I MHC and the coreceptor's role in cytotoxic T-cell activation. Here, we review the structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CD8 signaling that might provide the key to cytotoxic T-cell activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD8 Antigens / chemistry
  • CD8 Antigens / metabolism*
  • Histocompatibility Antigens Class I / chemistry
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Lymphocyte Activation / immunology*
  • Mice
  • Models, Immunological
  • Models, Molecular
  • Polymorphism, Genetic
  • Protein Binding
  • Protein Conformation
  • Protein Isoforms / chemistry
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary
  • Receptors, Antigen, T-Cell / chemistry
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / metabolism*
  • Solubility
  • Structure-Activity Relationship
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / metabolism

Substances

  • CD8 Antigens
  • Histocompatibility Antigens Class I
  • Protein Isoforms
  • Receptors, Antigen, T-Cell