Abstract
In recent years, substantial progress has been made towards understanding the molecular basis for CD8 binding to class I MHC and the coreceptor's role in cytotoxic T-cell activation. Here, we review the structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CD8 signaling that might provide the key to cytotoxic T-cell activation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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CD8 Antigens / chemistry
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CD8 Antigens / metabolism*
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / metabolism*
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Humans
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Lymphocyte Activation / immunology*
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Mice
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Models, Immunological
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Models, Molecular
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Polymorphism, Genetic
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Protein Binding
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Protein Conformation
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Protein Isoforms / chemistry
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Protein Isoforms / metabolism
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Protein Structure, Tertiary
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Receptors, Antigen, T-Cell / chemistry
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / metabolism*
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Solubility
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Structure-Activity Relationship
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Cytotoxic / metabolism
Substances
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CD8 Antigens
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Histocompatibility Antigens Class I
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Protein Isoforms
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Receptors, Antigen, T-Cell