EF-hand calcium-binding proteins

Curr Opin Struct Biol. 2000 Dec;10(6):637-43. doi: 10.1016/s0959-440x(00)00142-1.


The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their binding affinities. Recently determined structures of members of several newly identified protein families that contain the EF-hand motif in some of their domains, as well as of their complexes with target molecules, are throwing light on the surprising variety of functions that can be served by this simple and ingenious structural motif.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcium-Binding Proteins / chemistry*
  • Calcium-Binding Proteins / metabolism
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Signal Transduction


  • Calcium-Binding Proteins