Why Helicobacter pylori has Lewis antigens

Trends Microbiol. 2000 Dec;8(12):565-70. doi: 10.1016/s0966-842x(00)01875-8.


In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

Publication types

  • Review

MeSH terms

  • Bacterial Adhesion / physiology
  • Carbohydrate Sequence
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / immunology
  • Helicobacter pylori / pathogenicity*
  • Helicobacter pylori / physiology
  • Humans
  • Lewis Blood Group Antigens / chemistry
  • Lewis Blood Group Antigens / immunology
  • Lewis Blood Group Antigens / physiology*
  • Molecular Mimicry
  • Molecular Sequence Data
  • O Antigens / chemistry
  • O Antigens / immunology
  • O Antigens / physiology*
  • Virulence


  • Lewis Blood Group Antigens
  • O Antigens