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Review
, 25 (12), 596-601

The Regulation of Protein Function by Multisite Phosphorylation--A 25 Year Update

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Review

The Regulation of Protein Function by Multisite Phosphorylation--A 25 Year Update

P Cohen. Trends Biochem Sci.

Abstract

The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.

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