Association of fasting breath nitrous oxide concentration with gastric juice nitrate and nitrite concentrations and Helicobacter pylori infection

Dig Dis Sci. 2000 Oct;45(10):2054-7. doi: 10.1023/a:1005607120708.


Fasting breath nitrous oxide (N2O) concentration was determined in relation to pH, nitrate (NO3-) and nitrite (NO2-) concentrations in gastric juice, and Helicobacter pylori infection in 86 successive patients. N2O was measured with an infrared-photoacoustic analyzer. NO3- and NO2- were measured using the Griess reaction. Fasting breath N2O concentration in controls (87 +/- 21 ppb) was not significantly different from that in patients with gastric ulcer or other gastric lesions. Breath N2O was significantly correlated with gastric NO3- (P < 0.01) and was higher in patients with elevated gastric NO2- (246 +/- 87 ppb) than in patients without NO2- (75 +/- 13 ppb). Breath N2O did not differ significantly between subjects who were positive or negative for H. pylori. In conclusion, fasting breath N2O concentration is in some manner related to intragastric NO3- and NO2- concentrations. The possible use of measuring breath N2O as predictors of cancer needs further research.

MeSH terms

  • Adult
  • Aged
  • Breath Tests*
  • Fasting
  • Female
  • Gastric Juice / chemistry*
  • Gastritis / diagnosis*
  • Helicobacter Infections / diagnosis*
  • Humans
  • Male
  • Middle Aged
  • Nitrates / analysis*
  • Nitrous Oxide / analysis*
  • Predictive Value of Tests
  • Stomach Neoplasms / diagnosis
  • Stomach Ulcer / diagnosis*


  • Nitrates
  • Nitrous Oxide