Association of coffee consumption with gallbladder disease

Am J Epidemiol. 2000 Dec 1;152(11):1034-8. doi: 10.1093/aje/152.11.1034.


Coffee consumption was recently shown to protect against symptomatic gallbladder disease in men. The authors examined the relation of ultrasound-documented gallbladder disease with coffee drinking in 13,938 adult participants in the Third National Health and Nutrition Examination Survey, 1988-1994. The prevalence of total gallbladder disease was unrelated to coffee consumption in either men or women. However, among women a decreased prevalence of previously diagnosed gallbladder disease was found with increasing coffee drinking (p = 0.027). These findings do not support a protective effect of coffee consumption on total gallbladder disease, although coffee may decrease the risk of symptomatic gallstones in women.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Cholecystectomy / statistics & numerical data*
  • Cholelithiasis / epidemiology*
  • Cholelithiasis / etiology
  • Coffee / adverse effects*
  • Female
  • Gallbladder Diseases / epidemiology*
  • Gallbladder Diseases / etiology
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prevalence
  • Risk Factors
  • Sex Distribution
  • United States / epidemiology


  • Coffee