Hereditary catalase deficiencies and increased risk of diabetes

Lancet. 2000 Nov 25;356(9244):1820-1. doi: 10.1016/S0140-6736(00)03238-4.


Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic beta-cells and diabetes.

Publication types

  • Letter

MeSH terms

  • Acatalasia*
  • Adult
  • Catalase / genetics
  • Diabetes Mellitus / enzymology
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / genetics
  • Female
  • Humans
  • Hungary / epidemiology
  • Male
  • Oxidative Stress
  • Risk Factors


  • Catalase