Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy

Clin Infect Dis. 2001 Jan;32(1):144-8. doi: 10.1086/317535. Epub 2000 Dec 13.

Abstract

We describe 2 patients who were initially positive for antibodies to hepatitis B surface antigen and who experienced a strong and sudden increase of hepatitis B virus (HBV) replication during highly active antiretroviral therapy (HAART). We found that reactivation of HBV replication during HAART can occur independently of lamivudine resistance or withdrawal of lamivudine, and in spite of increasing CD4(+) cell counts.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / immunology
  • AIDS-Related Opportunistic Infections / virology*
  • Adult
  • Aged
  • Amino Acid Sequence
  • Anti-HIV Agents / adverse effects*
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active / adverse effects
  • DNA, Viral / blood
  • Hepatitis B / drug therapy
  • Hepatitis B / immunology
  • Hepatitis B / virology*
  • Hepatitis B virus / genetics
  • Hepatitis B virus / growth & development*
  • Humans
  • Lamivudine / adverse effects*
  • Lamivudine / therapeutic use
  • Male
  • Molecular Sequence Data
  • Reverse Transcriptase Inhibitors / adverse effects*
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Virus Activation*
  • Virus Replication

Substances

  • Anti-HIV Agents
  • DNA, Viral
  • Reverse Transcriptase Inhibitors
  • Lamivudine