Effects of depression and anxiety on mortality and quality-of-life 4 months after myocardial infarction

J Psychosom Res. 2000 Oct;49(4):229-38. doi: 10.1016/s0022-3999(00)00170-7.


Objective: The purpose of this study was to determine the impact of depression and anxiety on mortality and quality-of-life in patients hospitalized for an acute myocardial infarction (MI).

Methods: Questionnaire measures of depression and anxiety were completed during hospitalization by 288 MI patients. The main outcomes were mortality and quality-of-life, assessed by the Dartmouth COOP charts, at 4 months.

Results: A total of 25 patients died, 22 from cardiac causes, during the 4-month follow-up. Symptoms of depression and anxiety did not predict either cardiac or all-cause mortality. Severity of infarction, extent of heart failure, and a longer stay in hospital predicted mortality. Symptoms of depression and anxiety predicted 4-month quality-of-life among survivors, as did gender, partner status, occupational status, living alone, previous exercise behaviour, length of hospital admission, and Peel Index scores. In a multiple regression model, depression emerged as the strongest predictor of quality-of-life. State anxiety, severity of infarction, and partner status also entered the model.

Conclusion: Neither depression nor anxiety predicted mortality 4 months after MI. Both depression and anxiety predicted quality-of-life at 4 months among survivors.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anxiety / psychology*
  • Cause of Death
  • Depression / psychology*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / mortality*
  • Myocardial Infarction / psychology*
  • Myocardial Infarction / rehabilitation
  • Predictive Value of Tests
  • Quality of Life*
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Survival Rate
  • United Kingdom / epidemiology