Alternative splicing of the human PTEN/MMAC1/TEP1 gene

Biochim Biophys Acta. 2000 Dec 1;1494(3):282-5. doi: 10.1016/s0167-4781(00)00210-4.


The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Cell Line
  • Genes, Tumor Suppressor*
  • Humans
  • Molecular Sequence Data
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases / genetics*
  • RNA, Messenger / analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins*


  • RNA, Messenger
  • Tumor Suppressor Proteins
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human

Associated data

  • GENBANK/AF067844