Two-component systems in Pseudomonas aeruginosa: why so many?

Trends Microbiol. 2000 Nov;8(11):498-504. doi: 10.1016/s0966-842x(00)01833-3.


Screening the Pseudomonas aeruginosa genome has led to the identification of the highest number of putative genes encoding two-component regulatory systems of all bacterial genomes sequenced to date (64 and 63 encoding response regulators and histidine kinases, respectively). Sixteen atypical kinases, among them 11 devoid of an Hpt domain, and three independent Hpt modules were retrieved. These data suggest that P. aeruginosa possesses complex control strategies with which to respond to environmental challenges.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Gene Expression Regulation, Bacterial*
  • Genome, Bacterial
  • Histidine Kinase
  • Humans
  • Molecular Sequence Data
  • Protein Kinases / genetics*
  • Protein Kinases / metabolism
  • Pseudomonas aeruginosa / genetics*
  • Pseudomonas aeruginosa / physiology
  • Signal Transduction*


  • Bacterial Proteins
  • Protein Kinases
  • Histidine Kinase