Adolescent substance abuse is rising dramatically in the United States. This observation is especially troubling given the association between substance use and HIV, as well as other sexually transmitted diseases. Surprisingly, there have been few carefully constructed, controlled studies examining different treatment approaches with adolescent substance abusers. In our review of the literature, we note that family therapy and, to a lesser extent, cognitive behavioral therapy, received the most attention as intervention strategies with adolescents. Both approaches appear to have some success, although further research is necessary. In addition, developing and assessing strategies to improve family involvement in treatment requires additional investigation.