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Comparative Study
, 10 (8), 593-5

The Novel Drug CS-891 Inhibits 5alpha-reductase Activity in Freshly Isolated Dermal Papilla of Human Hair Follicles

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  • PMID: 11125319
Comparative Study

The Novel Drug CS-891 Inhibits 5alpha-reductase Activity in Freshly Isolated Dermal Papilla of Human Hair Follicles

S Niiyama et al. Eur J Dermatol.

Abstract

The local conversion of testosterone (T) to the more potent androgen dihydrotestosterone (DHT) by 5alpha-reductase (5aR) is implicated in the pathogenesis of androgenetic alopecia (AGA). Recently, the clinical effectiveness of finasteride, a selective type II 5aR inhibitor, in treating AGA has been documented, and these clinical studies have shown that circulating DHT is lowered by 60-70% in men taking finasteride. The source of the residual circulating DHT is presumed to be due to type I 5aR activity which is not affected by finasteride. Several novel compounds with potent dual inhibitory activity on both isoenzymes have been described and CS-891 is one of them. This compound may be likewise effective in the prevention or treatment of AGA. As a prerequisite for such an action CS-891 should be able to inhibit 5aR activity in its target tissue: the hair follicles (HF). Here we report on the capability of CS-891 to inhibit 5aR activity in dermal papillae (DP) of human HF.

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