Local anesthesia of genital mucosa with a lidocaine/prilocaine combination cream before laser therapy of human papillomavirus lesions

Eur J Dermatol. 2000 Dec;10(8):607-10.


The objective was to assess the efficacy of the lidocaine 2. 5%/prilocaine 2.5% combination cream during CO2 laser vaporisation treatment of human papillomavirus-related anogenital lesions. The cream was applied 1 to 30 min beforehand. Patients assessed pain using a visual analogue scale. Regardless of the site and lesion surface area, anaesthesia was greatest when the cream was applied 5 to 15 min before treatment. Extra-cervical lesions (vagina, vulva, perineum, anus) were globally less painful than cervical lesions. Lesion surface area is a decisive factor in pre-operative anaesthesia. Small surface-area lesions (< 1 cm2) had significantly greater anaesthesia than larger surface area-lesions (> 5 cm2) (p<0.00001). The study cream proved particularly useful for complete anaesthesia in ambulatory treatment of anal (70%) and urethral (60%) mucosa lesions compared to the uterine cervix (p = 0.03). In terms of anaesthetic efficacy and cost-related benefits, the lidocaine/prilocaine cream is an effective and interesting alternative to locoregional intra-lesional anaesthesia or even to general anaesthesia, for excision and destruction of human papillomavirus-related anogenital lesions.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Ambulatory Care
  • Anesthesia, Local / methods*
  • Condylomata Acuminata / diagnosis
  • Condylomata Acuminata / therapy*
  • Drug Combinations
  • Female
  • Humans
  • Laser Therapy*
  • Lidocaine / administration & dosage*
  • Male
  • Middle Aged
  • Ointments / administration & dosage
  • Pain Measurement
  • Papillomaviridae / isolation & purification*
  • Prilocaine / administration & dosage*
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / therapy*


  • Drug Combinations
  • Ointments
  • Prilocaine
  • Lidocaine