An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort

Diabetologia. 2000 Nov;43(11):1424-8. doi: 10.1007/s001250051549.


Aims/hypothesis: The UCP2-UCP3 gene region has been previously associated with obesity and diabetes. In a large representative cohort of Northern France (MONICA project), we studied the effect of a recently reported C/T polymorphism located in the 5' sequences of the UCP3 gene on anthropometric measurements and lipid profile. We also examined the association of this polymorphism with obesity and Type II (non-insulin-dependent) diabetes mellitus.

Methods: The -55 C/T polymorphism of the UCP3 gene has been genotyped in 1155 subjects from the MONICA project. Association studies were done with diabetes, obesity and related phenotypes. Results were ascertained in a second cohort of well-characterized Type II diabetic and control subjects.

Results: The variant T allele was associated with a decreased risk of developing Type II diabetes. Frequencies of the T allele were 13.3% compared with 22%, p = 0.04, in the diabetic and control groups, respectively. This observation was confirmed in the second cohort of French Type II diabetic (n = 171) and control (n = 124) subjects: 17.8% compared with 25%, p = 0.03. Moreover, subjects bearing the TT genotype had higher plasma total cholesterol and LDL-cholesterol concentrations (p = 0.0006 and p = 0.001, respectively) than subjects bearing wild or heterozygous genotypes.

Conclusion/interpretation: The UCP3 -55 C/T polymorphism was associated with a higher atherogenic profile and modified the risk for the development of Type II diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Blood Glucose / analysis
  • Body Constitution
  • Body Mass Index
  • Carrier Proteins / genetics*
  • Cholesterol, LDL / blood
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Female
  • France
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Insulin / blood
  • Ion Channels
  • Lipids / blood*
  • Male
  • Middle Aged
  • Mitochondrial Proteins
  • Obesity / blood
  • Obesity / genetics
  • Polymorphism, Genetic*
  • Risk Factors
  • Uncoupling Protein 3


  • Blood Glucose
  • Carrier Proteins
  • Cholesterol, LDL
  • Insulin
  • Ion Channels
  • Lipids
  • Mitochondrial Proteins
  • UCP3 protein, human
  • Uncoupling Protein 3