Mood alterations during deanol therapy

Psychopharmacology (Berl). 1979 Apr 11;62(2):187-91. doi: 10.1007/BF00427135.


An imbalance between central cholinergic and adrenergic influences may affect mood disorders. Of 38 patients taking high doses of deanol, a putative acetylcholine precursor, eight developed changes in mood: five became depressed and three became hypomanic. A predisposition is suggested as seven of these eight patients had histories of affective symptoms. There was no relationship between the changes in dyskinesias and mood. These observations have both practical and heuristic implications for the management of patients and for further research into the pharmacology of affective disorders and deanol.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Affective Symptoms / chemically induced*
  • Alcoholism / chemically induced
  • Clinical Trials as Topic
  • Deanol / adverse effects*
  • Deanol / therapeutic use
  • Double-Blind Method
  • Dyskinesia, Drug-Induced / drug therapy
  • Emotions / drug effects*
  • Ethanolamines / adverse effects*
  • Humans
  • Movement Disorders / drug therapy
  • Placebos


  • Ethanolamines
  • Placebos
  • Deanol