Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function

Med Sci Sports Exerc. 2000 Dec;32(12):2116-9. doi: 10.1097/00005768-200012000-00023.


Purpose: The purpose of this investigation was to examine the effects of differing amounts of beta-hydroxy-beta-methylbutyrate (HMB), 0, 36, and 76 mg x kg(-1) x d(-1), on hematology, hepatic and renal function during 8 wk of resistance training.

Methods: Thirty-seven, untrained collegiate males and were randomly assigned to one of the three groups, 0, 38, or 76 mg x kg(-1) x d(-1). Resistance training consisted of 10 exercises, performed 3 d x wk(-1) for 8 wk at 80% of their 1-repetition maximum. Blood and urine was obtained before training, 48 h after the initial session, 1 wk, 2 wk, 4 wk, and at 8 wk of resistance training. Blood was analyzed for glucose, blood urea nitrogen, hemoglobin, hepatic enzymes, lipid profile, total leukocytes, and individual leukocytes. Urine was analyzed for pH, glucose, and protein excretion.

Results: The 38 mg x kg(-1) x d(-1) group had a greater increase in basophils compared with 0 or 76 mg x kg(-1) x d(-1) groups (P < 0.05). No difference occurred in any other blood and urine measurements.

Conclusion: These data indicate that 8 wk of HMB supplementation (< or = 76 mg x kg(-1) x d(-1)) during resistance training had no adverse affects on hepatic enzyme function, lipid profile, renal function, or the immune system.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Chemical Analysis
  • Double-Blind Method
  • Exercise / physiology*
  • Humans
  • Kidney / drug effects*
  • Kidney / physiology*
  • Lipids / blood*
  • Liver / drug effects*
  • Liver / physiology*
  • Male
  • Valerates / pharmacology*


  • Lipids
  • Valerates
  • beta-hydroxyisovaleric acid