Tc-99m PMT whole-body scintigraphy for evaluated of therapeutic effect and for monitoring bone metastasis in a patient with hepatocellular carcinoma

Clin Nucl Med. 2000 Dec;25(12):1000-3. doi: 10.1097/00003072-200012000-00008.


Detection of metastatic lesions by bone scintigraphy is highly sensitive but has a low rate of specificity. Often bone metastases from hepatocellular carcinoma are not detected by bone scintigraphy because of low uptake or a photopenic area in the tumor. In contrast, Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) whole-body scintigraphy reflects tumor viability, and the specificity of detection is so high that tumor structure can be shown well. Tc-99m PMT whole-body scintigraphy was helpful for evaluating the response to therapy and monitoring the course of the patient described here with bone metastasis from hepatocellular carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / secondary*
  • Bone and Bones / diagnostic imaging
  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / secondary*
  • Humans
  • Liver Neoplasms / pathology*
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Sensitivity and Specificity
  • Tryptophan / analogs & derivatives*


  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m (Sn)-N-pyridoxyl-5-methyltryptophan
  • Tryptophan