The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate

Semin Dial. Nov-Dec 2000;13(6):381-4. doi: 10.1046/j.1525-139x.2000.00104.x.


Intravenous iron treatment is an important component of anemia therapy for patients on dialysis. Until recently iron dextran was the only parenteral form of iron available in the United States. This drug has been associated with occasional serious adverse reactions, including full-blown anaphylaxis. In 1999 the Food and Drug Administration approved a second form of iron for intravenous administration, sodium ferric gluconate in sucrose. It is expected that by the time of this publication, a third agent, iron saccharate will also be approved. In this review the comparative safety of these three agents is critically evaluated.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Anemia / drug therapy
  • Anemia / etiology
  • Ferric Compounds / administration & dosage
  • Ferric Compounds / therapeutic use*
  • Ferric Oxide, Saccharated
  • Glucaric Acid
  • Humans
  • Infusions, Intravenous
  • Iron-Dextran Complex / administration & dosage
  • Iron-Dextran Complex / adverse effects
  • Iron-Dextran Complex / therapeutic use*
  • Renal Dialysis* / adverse effects


  • Ferric Compounds
  • Iron-Dextran Complex
  • Ferric Oxide, Saccharated
  • Glucaric Acid
  • ferric gluconate