Correlation of Flow Cytometric Parameters and Transferrin Receptors With gallium-67 Scintigraphic Images in Lymphoma Patients

Nucl Med Commun. 2000 Oct;21(10):925-31. doi: 10.1097/00006231-200010000-00006.

Abstract

The purpose of this study was to determine the correlation of flow cytometric parameters and transferrin receptors with gallium-67 scintigraphic imaging results in Hodgkin's and non-Hodgkin's lymphoma patients. DNA content and cell cycle analyses were performed using flow cytometry and transferrin receptor analysis was carried out by the immunohistochemistry technique in 24 patients aged between 16 and 62 years. All patients underwent gallium-67 scintigraphy, and tumour to background ratios were calculated. The findings were correlated with computed tomography and/or magnetic resonance imaging. A strong relationship was observed between flow cytometry and transferrin receptor expression with gallium-67 tumour scintigraphy [P = 0.005, r = 0.054 and P = 0.038, r = 0.54 (Spearman test), respectively]. The results of this study show that there is a close correlation between each of these modalities and, as they reflect the biological activity of the tumour, together they have a major role in treatment and follow-up.

MeSH terms

  • Adolescent
  • Adult
  • Cell Cycle
  • DNA, Neoplasm / analysis
  • Female
  • Flow Cytometry
  • Gallium Radioisotopes*
  • Hodgkin Disease / diagnostic imaging
  • Hodgkin Disease / metabolism
  • Hodgkin Disease / pathology
  • Humans
  • Immunohistochemistry
  • Lymphoma / diagnostic imaging*
  • Lymphoma / metabolism*
  • Lymphoma / pathology
  • Lymphoma, Non-Hodgkin / diagnostic imaging
  • Lymphoma, Non-Hodgkin / metabolism
  • Lymphoma, Non-Hodgkin / pathology
  • Male
  • Middle Aged
  • Prognosis
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Receptors, Transferrin / metabolism*
  • Tomography, X-Ray Computed

Substances

  • DNA, Neoplasm
  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Transferrin