The influence of emetine on the induction of interferon by poly-I: poly-C in Swiss mice

J Gen Virol. 1975 Feb;26(2):197-200. doi: 10.1099/0022-1317-26-2-197.

Abstract

The effect of emetine on the in vivo production of interferon by Swiss mice stimulated with poly-i: poly-C, was studied. 100 mug of emetine per mouse yielded a 16-fold increase in interferon production. Maximal production of interferon was achieved 2 h after the simultaneous injection of emetine and poly-I: poly-C.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Emetine / pharmacology*
  • Interferons / biosynthesis*
  • Mice
  • Poly I-C / pharmacology*

Substances

  • Interferons
  • Poly I-C
  • Emetine